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Tuscan Chicken Casserole covered with Italian bread crumbs and parmesan cheese

Creamy Tuscan Chicken and Spaghetti Casserole

Creamy alfredo sauce mixed with chicken and spaghetti with sun-dried tomatoes, mushroom and spinach accents make an easy Creamy Tuscan Chicken and Spaghetti Casserole.
Course Main Course
Cuisine American
Keyword Creamy Tuscan Chicken and Spaghetti Casserole
Prep Time 15 minutes
Cook Time 20 minutes
Total Time 35 minutes
Servings 8 servings
Calories 318kcal
Author Jennifer @ Plowing Through Life


  • 2 cups shredded chicken cooked
  • 1/2 pound cut spaghetti cooked
  • 1 cup mushrooms sliced or quartered
  • 1 cup fresh spinach chopped
  • 15 ounce jar garlic Alfredo sauce
  • 3 ounces sundried tomatoes cut into thin strips
  • 1/4 cup grated Parmesan cheese
  • 1/4 cup Italian bread crumbs


  • Cook spaghetti and chicken (if necessary). Drain and return spaghetti to pot.
  • Mix in chicken, mushrooms, spinach, Alfredo sauce and tomatoes.
  • Pour into a greased 9 x 13 inch casserole dish.
  • Mix bread crumbs and parmesan cheese together and sprinkle evenly over casserole.
  • Bake at 350°F for 20 - 30 minutes until heated through.


  • Slice sun-dried tomatoes into small pieces to help spread the delicious flavors throughout more bites
  • Slice or quarter mushrooms
  • Can prepare and shred chicken especially for this recipe, but we like to use leftover rotisserie chicken or even a can of shredded chicken to save time
  • If garlic alfredo sauce isn't available add minced garlic or fresh garlic to regular alfredo sauce
  • We like cut spaghetti because it's easier for many of us, including our young kids to eat, but any type of pasta can be used
  • If bread crumb topping starts to brown cover with foil to prevent burning, but allow casserole to heat through
  • Chicken casserole reheats well, but may need extra sauce added to maximize flavor
  • Casserole can be frozen in an airtight container for up to three months and reheated - I typically add more sauce or cheese when reheating a frozen chicken and spaghetti casserole to help keep it moist


Calories: 318kcal | Carbohydrates: 32g | Protein: 18g | Fat: 13g | Saturated Fat: 6g | Cholesterol: 64mg | Sodium: 513mg | Potassium: 575mg | Fiber: 3g | Sugar: 6g | Vitamin A: 493IU | Vitamin C: 5mg | Calcium: 67mg | Iron: 2mg